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A finishing experiment evaluated substitution of corn with crop residues in diets containing wet distillers grains. Corn stover, corn cobs, and wheat straw were alkaline treated at 50% moisture or fed without chemical treatment at 20% inclusion. Chemical treatment improved performance compared to untreated. Compared to control (10% roughage), treated diets had similar performance and carcass merit. Economic analysis revealed $6.46, $21.42, and $36.30 average profit per head advantage for diets containing treated residues relative to control when corn was priced at $3.00, $4.50, and $6.00 per bushel. Feeding chemically treated crop residues and wet distillers grains is a cost-effective strategy for replacing corn in feedlot diets without compromising performance or carcass quality.