Authors
Sabeeha S. Merchant, University of California at Los Angeles, Los Angeles, CA
Simon E. Prochnik, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Olivier Vallon, CNRS, Université Paris 6, Institut de Biologie Physico-Chimique, 75005 Paris, France
Elizabeth H. Harris, Department of Biology, Duke University, Durham, NC 27708, USA
Steven J. Karpowicz, University of California at Los Angeles, Los Angeles, CA
George B. Witman, Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA
Astrid Terry, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Asaf Salamov, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Lillian K. Fritz-Laylin, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
Laurence Maréchal-Drouard, nstitut de Biologie Moléculaire des Plantes, CNRS, 67084 Strasbourg Cedex, France
Wallace F. Marshall, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA
Liang-Hu Qu, Biotechnology Research Center, Zhongshan University, Guangzhou 510275, China
David R. Nelson, Department of Molecular Sciences and Center of Excellence in Genomics and Bioinformatics, University of Tennessee, Memphis, TN 38163, USA
Anton A. Sanderfoot, Department of Plant Biology, University of Minnesota, St. Paul, MN 55108, USA
Martin H. Spalding, Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011, USA
Vladimir V. Kapitonov, Genetic Information Research Institute, Mountain View, CA 94043, USA
Qinghu Ren, The Institute for Genomic Research, Rockville, MD 20850, USA
Patrick Ferris, Plant Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA
Erika Lindquist, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Harris Shapiro, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Susan M. Lucas, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Jane Grimwood, Stanford Human Genome Center, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Jeremy Schmutz, Stanford Human Genome Center, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Chlamydomonas Annotation Team
Vadim N. Gladyshev, University of Nebraska-LincolnFollow
JGI Annotation Team
Igor V. Grigoriev, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Daniel S. Rokhsar, U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA
Arthur R. Grossman, Department of Plant Biology, Carnegie Institution, Stanford, CA 94306, USA
Date of this Version
10-12-2007
Abstract
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ~120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Comments
Published in SCIENCE VOL 318 12 OCTOBER 2007. Copyright 2007. Used by permission.