Papers in the Biological Sciences

 

Authors

Andreas Rosenwald, 1The Lymphoma/Leukemia Molecular Profiling Project
George Wright, National Cancer Institute, NIH, Bethesda, Maryland
Adrian Wiestner, National Cancer Institute, NIH, Bethesda, Maryland
Wing Chan, 1The Lymphoma/Leukemia Molecular Profiling Project
Joseph Connors, 1The Lymphoma/Leukemia Molecular Profiling Project
Elias Campo, 1The Lymphoma/Leukemia Molecular Profiling Project
Randy Gascoyne, 1The Lymphoma/Leukemia Molecular Profiling Project
Thomas Grogan, 1The Lymphoma/Leukemia Molecular Profiling Project
Konrad Muller-Hermelink, 1The Lymphoma/Leukemia Molecular Profiling Project
Erlend B. Smeland, 1The Lymphoma/Leukemia Molecular Profiling Project
Michael Chiorazzi, 1The Lymphoma/Leukemia Molecular Profiling Project
Jena M. Giltnane, 1The Lymphoma/Leukemia Molecular Profiling Project
Elaine M. Hurt, 1The Lymphoma/Leukemia Molecular Profiling Project
Hong Zhao, 1The Lymphoma/Leukemia Molecular Profiling Project
Lauren Averett, 1The Lymphoma/Leukemia Molecular Profiling Project
Sarah Henrickson, 1The Lymphoma/Leukemia Molecular Profiling Project
Liming Yang, 1The Lymphoma/Leukemia Molecular Profiling Project
John Powell, 1The Lymphoma/Leukemia Molecular Profiling Project
Wyndham H. Wilson, Lymphoma/Leukemia Molecular Profiling ProjectFollow
Elaine S. Jaffe, Lymphoma/Leukemia Molecular Profiling ProjectFollow
Richard Simon, 1The Lymphoma/Leukemia Molecular Profiling Project
Richard D. Klausner, 1The Lymphoma/Leukemia Molecular Profiling Project
Emilio Montserrat, 1The Lymphoma/Leukemia Molecular Profiling Project
Francesc Bosch, 1The Lymphoma/Leukemia Molecular Profiling Project
Timothy Greiner, University of Nebraska - Lincoln
Dennis D. Weisenburger, 1The Lymphoma/Leukemia Molecular Profiling Project
Warren G. Sanger, 1The Lymphoma/Leukemia Molecular Profiling Project
Bhavana J. Dave, 1The Lymphoma/Leukemia Molecular Profiling Project
James C. Lynch, 1The Lymphoma/Leukemia Molecular Profiling Project
Julie Vose, 1The Lymphoma/Leukemia Molecular Profiling Project
James O. Armitage, 1The Lymphoma/Leukemia Molecular Profiling Project
Richard I. Fisher, 1The Lymphoma/Leukemia Molecular Profiling Project
Thomas P. Miller, 1The Lymphoma/Leukemia Molecular Profiling Project
Michael LeBlanc, 1The Lymphoma/Leukemia Molecular Profiling Project
German Ott, 1The Lymphoma/Leukemia Molecular Profiling Project
Stein Kvaloy, 1The Lymphoma/Leukemia Molecular Profiling Project
Harald Holte, 1The Lymphoma/Leukemia Molecular Profiling Project
Jan Delabie, 1The Lymphoma/Leukemia Molecular Profiling Project
Louis M. Staudt, 1The Lymphoma/Leukemia Molecular Profiling Project

Date of this Version

2-2003

Comments

Published in CANCER CELL: FEBRUARY 2003, VOL. 3 . Copyright 2003. Used by permission.

Abstract

We used gene expression profiling to establish a molecular diagnosis of mantle cell lymphoma (MCL), to elucidate its pathogenesis, and to predict the length of survival of these patients. An MCL gene expression signature defined a large subset of MCLs that expressed cyclin D1 and a novel subset that lacked cyclin D1 expression. A precise measurement of tumor cell proliferation, provided by the expression of proliferation signature genes, identified patient subsets that differed by more than 5 years in median survival. Differences in cyclin D1 mRNA abundance synergized with INK4a/ARF locus deletions to dictate tumor proliferation rate and survival. We propose a quantitative model of the aberrant cell cycle regulation in MCL that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy.

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