Published Research - Department of Chemistry

 

Date of this Version

9-12-2011

Citation

Angew Chem Int Ed Engl. 2011 September 12; 50(38): 8895–8899. doi:10.1002/anie.201103365.

Comments

Copyright 2011. Used by permission.

Abstract

Combinatorial approaches to catalysis have made an impact in targeted transformation development, including Ag-mediated carbene insertion,[1] Sc-pybox-based asymmetric cyclopropanation,[2] and Rh/Ir-based asymmetric hydrogenation.[3] Useful design elements have emerged from these studies, e.g. the value of ligand self assembly,[4] or of the inclusion of peptide-like structural elements[5],[6],[7] in building ligand arrays. Efficient screening methods are of paramount importance for such efforts. Methods based on fluorescence,[8] REMPI,[9] MS,[10] NMR,[11] and IR thermography[12] have appeared. A chromophore may be installed into the substrate[13] or product[14] of the reaction under study. Alternatively, one can exploit chromophores inherent in proteins[15] or enzyme-associated reactions,[16] and use these sensors to report back on product formation and composition.

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