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The effects of invasive vertebrate species on agriculture, human health and safety, and the environment are a growing concern around the world. The number of incidents of invasive species causing harm continues to climb with increased worldwide travel and transportation of goods. The focus for many decades was on invasive pathogens, plants, and invertebrates because they can greatly affect human and animal health and food supplies. In recent years, invasive vertebrate species, such as rats, feral pigs, and feral cats, have garnered more attention because the magnitude of their impacts have been repeatedly highlighted in the media. In response, better methods of prevention, detection, and management of invasive species have been developed. For example, several eradications of invasive vertebrates on islands have been successful, although management on mainland settings is generally much more challenging.