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We present first evidence for WW + WZ production in lepton + jets final states at a hadron collider. The data correspond to 1.07 fb-1 of integrated luminosity collected with the D0 detector at the Fermilab Tevatron in pp collisions at √s = 1.96 TeV. The observed cross section for WW + WZ production is 20.2 ± 4.5 pb, consistent with the standard model and more precise than previous measurements in fully leptonic final states. The probability that background fluctuations alone produce this excess is <5.4 x>10-6, which corresponds to a significance of 4.4 standard deviations.