Biochemistry, Department of
Stress-triggered Activation of the Metalloprotease Oma1 Involves Its C-terminal Region and Is Important for Mitochondrial Stress Protection in Yeast
Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 19, pp. 13259–13272, May 9, 2014
Background: Oma1 is a conserved membrane-bound protease that forms a high molecular mass complex.
Results: Oma1 activity is induced by stress stimuli and required for survival. The activation is linked to changes in Oma1 oligomer stability and involves its C-terminal region.
Conclusion: Oma1 function is activated by mitochondrial stress and is important for stress tolerance.
Significance: Novel insights into Oma1 function and a potential stress activation mechanism are provided.
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