Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 20, pp. 14068–14079, May 17, 2013
Background: HARE mediates systemic clearance of hyaluronan (HA), which turns over continuously in tissues.
Results: HARE uptake of 40–400-kDa, but not larger or smaller, HA stimulated NF-κB activation.
Conclusion: HA-HARE signal complexes activate NF-κB and gene transcription only with optimally sized HA.
Significance: HARE responsiveness to a narrow size range ofHAdegradation products may be a sensing system to detect tissue ECM stress.