Papers in the Biological Sciences

 

Date of this Version

3-21-2010

Document Type

Article

Citation

J Med Primatol 39 (2010) 356–360; doi:10.1111/j.1600-0684.2010.00416.x

Comments

U.S. Government work

Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

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