Published Research - Department of Chemistry

 

Date of this Version

2013

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 50, pp. 36116–36128

Comments

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: The TCA cycle is a central metabolic pathway that facilitates the adaption of bacteria to a nutrient-limited environment.

Results: Inactivation of CcpE in Staphylococcus aureus resulted in a decreased transcription of the aconitase encoding gene citB, and reduced TCA cycle activity.

Conclusion: CcpE affects the TCA cycle via direct transcriptional control of citB.

Significance: This is the first positive regulator of TCA cycle activity identified in this pathogen.

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