Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 50, pp. 36116–36128
Background: The TCA cycle is a central metabolic pathway that facilitates the adaption of bacteria to a nutrient-limited environment.
Results: Inactivation of CcpE in Staphylococcus aureus resulted in a decreased transcription of the aconitase encoding gene citB, and reduced TCA cycle activity.
Conclusion: CcpE affects the TCA cycle via direct transcriptional control of citB.
Significance: This is the first positive regulator of TCA cycle activity identified in this pathogen.