Organic Radical Contrast Agents for Magnetic Resonance Imaging

Authors

Andrzej Rajca, University of Nebraska - LincolnFollow
Ying Wang, University of Nebraska-Lincoln
Michael Boska, University of Nebraska Medical Center
Joseph T. Paletta, University of Nebraska-Lincoln
Arnon Olankitwanit, University of Nebraska - LincolnFollow
Michael A. Swanson, University of Denver
Deborah G. Mitchell, University of Denver
Sandra S. Eaton, University of Denver
Gareth R. Eaton, University of Denver
Suchada Rajca, University of Nebraska-LincolnFollow

Date of this Version

2012

Citation

J Am Chem Soc. 2012 September 26; 134(38): 15724–15727.

Comments

Copyright 2012 Am Chemical Soc. Used by permission.

Abstract

We report a molecular design that provides an intravenously injectable organic radical contrast

agent (ORCA) that has molecular r₁ ≈ 5 mM⁻¹s⁻¹. The ORCA is based on spirocyclohexyl

nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine

dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced

MRI in mice for over 1 h.