Published Research - Department of Chemistry

 

Date of this Version

2012

Citation

J Am Chem Soc. 2012 September 26; 134(38): 15724–15727.

Comments

Copyright 2012 Am Chemical Soc. Used by permission.

Abstract

We report a molecular design that provides an intravenously injectable organic radical contrast

agent (ORCA) that has molecular r1 ≈ 5 mM−1s−1. The ORCA is based on spirocyclohexyl

nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine

dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced

MRI in mice for over 1 h.

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