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A computational constitutive model was developed to predict damage and fracture failure of asphalt concrete mixtures. Complex heterogeneity and inelastic mechanical behavior are addressed by the model by using finite-element methods and elastic– viscoelastic constitutive relations. Damage evolution due to progressive cracking is represented by randomly oriented interface fracture, which is governed by a newly developed nonlinear viscoelastic cohesive zone model. Computational simulations demonstrate that damage evolution and failure of asphalt concrete mixtures is dependent on the mechanical properties of the mixture. This approach is suitable for the relative evaluation of asphalt concrete mixtures by simply employing material properties and fracture properties of mixture components rather than by performing expensive laboratory tests recursively, which are typically required for continuum damage mechanics modeling.