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This NebGuide addresses some of the current concerns about atrazine and water quality. Included are some questions and answers about atrazine regarding toxicity, EPA guidelines, presence in water supplies, weed resistance and best management practices. What is atrazine? Atrazine is a herbicide that selectively controls broadleaf (dicot) weeds, such as pigweed, cocklebur, velvetleaf and certain grass weeds in fields of corn and sorghum. Selective control means that the target weeds are controlled, with little or no injury to the crop. Atrazine is well tolerated by actively growing corn and sorghum, which absorb and metabolize the herbicide and thereby detoxify it.