Updated threshold dose-distribution data for sesame

Authors

Paul J. Turner, Imperial College London
Magdalena Gretzinger, Imperial College London
Nandinee Patel, Imperial College London
Helen A. Brough, Guy's and St. Thomas' NHS Foundation Hospital, King's College London
R. Sharon Chinthrajah, Stanford University School of Medicine
Motohiro Ebisawa, National Hospital Organization Sagamihara National Hospital
Arnon Elizur, Yitzhak Shamir Medical Center, Tel Aviv University
Jennifer J. Koplin, The Murdoch Children’s Research Institute, University of Melbourne
Rachel L. Peters, The Murdoch Children’s Research Institute, University of Melbourne
Natasha Purington, Stanford University School of Medicine
Anna Nowak-Wegrzyn, New York University Langone Health, University of Warmia and Mazury
Sarah Saf, Icahn School of Medicine at Mount Sinai, Hôpital d'Enfants Armand Trousseau
Hugh A. Sampson, Icahn School of Medicine at Mount Sinai
Joost Westerhout, The Netherlands Organisation of Applied Scientific Research, Utrecht
W. Marty Blom, The Netherlands Organisation of Applied Scientific Research, Utrecht
Joseph L. Baumert, University of Nebraska-LincolnFollow
Geert F. Houben, The Netherlands Organisation of Applied Scientific Research, Utrecht
Benjamin C. Remington, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2022

Citation

Allergy. 2022;77:3124–3162. DOI: 10.1111/all.15364

Comments

Open access.

Abstract

Sesame is classified as a “major” food allergen for which mandatory disclosure is required. Understanding reaction thresholds and how these vary within the allergic population is crucial in providing appropriate dietary advice to patients, providing guidance to the food industry, and informing dosing regimens for oral food challenges (FC). However, the largest data series used to derive a threshold dose-distribution for sesame included blinded challenge data from just 40 individuals.¹ Data from low-dose, open FC can be used to supplement that from blinded FC, reducing uncertainty in estimating threshold dose-distributions for allergenic foods which otherwise lack sufficient data.² We, therefore, undertook a systematic search of the literature and performed dose-distribution modelling of individual patient FC data (including open FC) to update estimated eliciting doses for sesame.