Evolutionary Characterization of the Pandemic H1N1/ 2009 Influenza Virus in Humans Based on Non-Structural Genes

Authors

Chengmin Wang, Chinese Academy of Sciences
Yanyu Zhang, Beijing Institute of Transfusion Medicine
Bin Wu, Chinese Academy of Sciences
Shelan Liu, Zhejiang Center for Disease Control and Prevention
Ping Xu, Chinese Academy of SciencesFollow
Yanmin Lu, Chinese Academy of Sciences
Jing Luo, Chinese Academy of SciencesFollow
Dale L. Nolte, USDA-APHIS-Wildlife ServicesFollow
Thomas J. DeLiberto, USDA/APHIS/WS National Wildlife Research CenterFollow
Mingxing Duan, Tsinghua UniversityFollow
Hong Zhang, Chinese Academy of Sciences
Hongxuan He, Chinese Academy of SciencesFollow

Document Type

Article

Date of this Version

2013

Citation

PLoS ONE 8(2): e56201; doi:10.1371/journal.pone.0056201

Abstract

The 2009 influenza pandemic had a tremendous social and economic impact. To study the genetic diversity and evolution of the 2009 H1N1 virus, a mutation network for the non-structural (NS) gene of the virus was constructed. Strains of the 2009 H1N1 pandemic influenza A virus could be divided into two categories based on the V123I mutation in the NS1 gene: G1 (characterized as 123 Val) and G2 (characterized as 123 Ile). Sequence homology analysis indicated that one type of NS sequence, primarily isolated from Mexico, was likely the original type in this pandemic. The two genotypes of the virus presented distinctive clustering features in their geographic distributions. These results provide additional insight into the genetics and evolution of human pandemic influenza H1N1.