U.S. Department of Agriculture: Animal and Plant Health Inspection Service


Date of this Version



Jackson, K.C., T. Gidlewski, J.J. Root, A.M. Bosco-Lauth, R.R. lash, J.R. Harmon, A.C. Brault, N.A. Panella, W.L. Nicholson, and N. Komar. 2019. Bourbon virus in wild and domestic animals, Missouri, USA, 2012-2013. Emerging Infectious Diseases 25(9):1752-1753. doi: 10.3201/eid2509.181902


Bourbon virus (BRBV) was first isolated from a febrile patient with a history of tick bites in Bourbon County, Kansas, USA; the patient later died from severe illness in 2014 (1). Several additional human BRBV infections were reported subsequently from the midwestern and southern United States (2). BRBV belongs to the family Orthomyxoviridae, genus Thogotovirus, which is distributed worldwide and includes Araguari, Aransas Bay, Dhori, Jos, Thogoto, and Upolu viruses (1,3). Thogoto and Dhori viruses have been associated with human disease (4–6). Viruses within the genus Thogotovirus have been associated with hard or soft ticks (7). Recent studies suggest that the lone star tick (Amblyomma americanum) is involved with BRBV transmission (2,3,8). These ticks feed primarily on mammals, which might play a role in BRBV ecology