The adoption of Information and Communication Technologies (ICTs) has become a general trend in virtually all professions including the academia. Professionals in the academia are adopting ICTs with a view of offering the services that they have traditionally provided without these technologies so as to attain their strategic academic objectives. Since 2004, the Makerere University has taken up ICTs as a strategic enabler to fulfill the Makerere University’s strategic objectives (Makerere University, 2014). One of the key features of this movement was the adoption of Internet in academic and administrative work of the University. It should be noted that Internet has evolved since then to the advent of Web 2.0 and social software. This paper therefore assesses the adoption of Web 2.0 and social software in the teaching and learning in Makerere University. It findings give the overall adoption picture of web 2.0 technologies in teaching and learning in Makerere University. It notes minimal utilization of web 2.0 technologies in teaching and learning hence requiring strong institutional intervention both at operational and policy levels.