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Information and Communication Technology (ICT) has become a force that has changed many aspects of the way we live and every aspect of human endeavor such as education, medicine, business, law and engineering. Education is a socially oriented activity and quality education has traditionally been associated with teachers having high degrees of personal and face-to-face contact with students. But with the world moving rapidly into digital media and information, the role of ICT in education is becoming more and more important. However, indicators on technology uptake and use in education in the secondary schools in Ghana are missing and most of the schools continues to use the traditional method for knowledge dissemination. This study assess the adoption and use of ICT in teaching and learning in secondary schools in Ghana. The study focused on the secondary schools in the southern sector of Ghana (Western, Central, Greater Accra, Volta and Eastern Regions). The qualitative research method was used in this study. The research established that the ages and gender of the respondents largely affected their adoption and usage of ICT as the students, young and male teachers had more knowledge and interest in the use of ICT for teaching and learning. There was disparities in the provision of computers and ICT facilities at the secondary schools as the schools in the urban areas had some ICT facilities although they were found to be inadequate, not properly ventilated, not spacious enough and have poor lightening system. However, some of the teachers were having their own PCs (personal computers, laptops or tablets) for use although they always do not use them for teaching and learning. As a result, the impact of ICT in teaching and learning at the secondary schools were minimal.