The world is currently faced with various challenges which have become a major drawback in achieving sustainable development across the developing world. One way to address these challenges is to ensure that countries work towards achieving the United Nations’ Sustainable Development Goals (SDGs), which require a number of stakeholders to intervene if these challenges must be reduced for the benefit of humanity, and one such stakeholder is the library and information sector. This paper uses insights from the Development and Access to Information (DA2I) framework to thematically examine and synthesize the contribution of library and information services in achieving SDGs through exploring their contributions to the various economic and social transformation drivers based on Uganda’s Vision 2040. Data were collected through reviews of online peer-reviewed and grey literature published between the year 2001 and 2019. It is observed that effective and sustainable management of library and information services will be central to the attainment of all the SDGs as reflected in the Uganda’s Vision 2040. The government of Uganda therefore needs to provide the needed status for this sector and put it on its agenda to usher a new spirit of library and information services professionalism that will go a long way to enhance literacy and enlightenment that is needed if Uganda is to achieve the SDGs as reflected in its Vision 2040 plan.