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The paradigm shift in medical academic practices in Pakistan is becoming a challenge for medical librarians. Majority of medical schools in Pakistan have started problem based learning, undergrads medical research program and Postgraduate programs. This quantitative study aims to investigate the information literacy program in medical libraries situated in the Khyber Pakhtunkhwa (KP) province of Pakistan. The questionnaire administered with in 20 medical colleges libraries using Google Forms as an instrument for data collection and distributed link among all medical college librarians of the province. Findings of the study revealed that majority medical libraries are providing informal information literacy using orientation, bibliographic instructions and occasional lectures as method. The target audience of the information literacy was newly inducted Students. The effectiveness and importance of information literacy program for medical students considered by (87.50%) librarians. This study by large will contribute to modify the current practices of information literacy by the medical libraries.