The study examined the awareness and competency level of undergraduates for entrepreneurship opportunities in library and information science profession in University Of Nigeria, Nsukka. Six research questions guided the study. Descriptive survey research design was adopted for the study. The population of the study comprised of the entire undergraduates in LIS, University Of Nigeria, Nsukka, which is 240. 43 Final year students were purposively sampled because they had spent more years in the system, are on the way to the labour market, have undertaken most of the courses in the curriculum that will prepare them for the needed skills and competency in entrepreneurship and marketing opportunities in library and information science. The instrument used for data collection is questionnaire and content analysis of LIS curriculum. Data collected was analysed and presented using frequency distribution table, percentage, and mean score. The findings revealed that, that most of the courses that will prepare the students for entrepreneurship and marketing opportunities in LIS are available in LIS, University Of Nigeria, Nsukka curriculum. The students have high awareness level and positive perception of the various entrepreneurship opportunities in library and information science profession. The students also possess high competence in undertaking entrepreneurship opportunities in library and information science profession, except in some ICT based entrepreneurship opportunities in library and information science profession. Non-challant attitude of students, lack of functional workshop and laboratories, lack of ICT skills, lack of curriculum review and inadequate ICT courses in the curriculum are the major challenges affecting the acquisition of competency by students. The study recommended among other things that, More ICT courses should be included into the curriculum ICT based courses like Database management, web publishing, software technology, library application packages, introduction to internet and virtual library and data communications, urgent curriculum review etc.