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The purpose of this study was to know the experience of Library and Information Science (LIS) professionals of Pakistan about creation of the institutional repositories (IRs) using DSpace at their institutions. This study also explored the success factors, problems in the implementation of the DSpace and solutions. To meet the purpose, study was conducted in the multiple phases. In the first phase, the relevant literature was reviewed. On the basis of reviewed literature, an interview guide was developed for data collection. Data was collected from LIS professionals of renowned Lahore based universities such as Lahore University of Management Sciences (LUMS), University of Management & Technology (UMT) and COMSATS Institute of Information Technology. Results of the study revealed that lack of trained staff was one of the major problems in creating the institutional repositories. This study being first of its kind is unique in terms of topic and nature. It involved professionals of LUMS, COMSATS and UMT for their experience in creation of IRs using DSpace. This study is of value for organizations and professionals to understand the problems involved and their possible solutions for successful implementation of DSpace for creation of IRs.