The study investigated how perceptions and IT competencies of academic librarians influenced their use of Cloud-Based Storage (CBS) systems in libraries in South-West Nigeria. Primary data were collected from 127 academic librarians working in 11 university libraries across six Southwestern states of Nigeria. The answers from these valid copies of the questionnaire were descriptively (frequency count and percentage) and inferentially (regression statistics) analyzed using SPSS version 23. The findings revealed that the librarians had high perceptions for the use of CBS systems and also their IT competencies were on the high side. The perceptions and IT competencies of librarians significantly influenced the use of CBS systems in Nigerian academic libraries. In addition, the findings also indicated that perceptions and IT competencies of librarians jointly significantly influenced the use of CBS systems in Nigerian academic libraries. The significant outcomes of this study are that the perceptions and IT competencies of librarians have been found to be positively associated with the use of CBS systems in academic libraries in South-West Nigeria. Hence, a critical effort is required to improve the librarians’ encouraging perception and level of optimism of IT competency in increasing the awareness and application of CBS systems and other library technologies among librarians in South-West Nigeria and Nigeria at large.