The study investigated the influence of information literacy skills on infopreneurship intentions of Library and Information Science (LIS) undergraduates in public universities in South-West Nigeria. Two theories supported the study, namely; the theory of planned behaviour and the big six information literacy model. The Descriptive survey research design was adopted for the study and the population comprised 668 LIS undergraduates in their final year (400 level) across three public universities in South-West Nigeria. Total enumeration technique was used to cover all the target respondents. An adapted questionnaire was used as data collection instrument. Five hundred and eighty responses were returned from the online google form sent to 668 respondents, representing 86.8% response rate. Findings revealed that there was a positive and significant correlation between information literacy skills and infopreneurship intentions of LIS undergraduates in public universities in South-West Nigeria (t=7.765; B=0.294; p<0.05). The study concluded that information literacy skills are critical variables that can predict and facilitate positive infopreneurship intentions among LIS undergraduates in public universities in South-West Nigeria and recommended among others that public universities in Nigeria should explore the idea of equipping LIS undergraduates with the requisite information literacy skills to facilitate start-up of information businesses after graduation.