Nutrition and Health Sciences, Department of


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Thompson, M.; Ulu, A.; Mukherjee, M.; Yuil-Valdes, A.G.; Thoene, M.; Van Ormer, M.; Slotkowski, R.; Mauch, T.; Anderson-Berry, A.; Hanson, C.K.; et al. Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development. Biomedicines 2023, 11, 171. 10.3390/biomedicines11010171


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Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.