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An account of global initiatives in invasive alien species, including vertebrates, was presented based on the author’s experience and that of colleagues, mainly in the developing world. The account focused on those programs which highlight typical problems or best practice for design and which promised improvements in the future. Some of the characteristics of these programs were described and discussed. Techniques used in vertebrate control programs, especially in developing island states, were also described with a commentary on their efficacy and suitability for use. Finally, some future directions were recommended in terms of the design of in-country and regional programs and the methodology best suited for these programs.