Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 27, pp. 20002–20013, July 5, 2013
Background: Mercaptopyruvate sulfurtransferase (MST) generates H2S, a signaling molecule.
Results: The detailed kinetics and crystal structure of human MST with bound substrate are reported.
Conclusion: Thioredoxin is the preferred persulfide acceptor from MST.
Significance: The structure provides molecular insights into activation and stabilization of MST reaction intermediates.