CoxPhLb: An R Package for Analyzing Length Biased Data under Cox Model

Authors

Chi Hyun Lee, University of Massachusetts Amherst
Heng Zhou, Merck & Co., Inc.
Jing Ning, The University of Texas MD Anderson Cancer Center
Diane D. Liu, The University of Texas MD Anderson Cancer Center
Yu Shen, The University of Texas MD Anderson Cancer Center

Date of this Version

6-2020

Document Type

Article

Citation

The R Journal (June 2020) 12(1); Editor: Michael J. Kane

Comments

Copyright 2020, The R Foundation. Open access material. License: CC BY 4.0 International

Abstract

Data subject to length-biased sampling are frequently encountered in various applications including prevalent cohort studies and are considered as a special case of left-truncated data under the stationarity assumption. Many semiparametric regression methods have been proposed for length biased data to model the association between covariates and the survival outcome of interest. In this paper, we present a brief review of the statistical methodologies established for the analysis of length-biased data under the Cox model, which is the most commonly adopted semiparametric model, and introduce an R package CoxPhLb that implements these methods. Specifically, the package includes features such as fitting the Cox model to explore covariate effects on survival times and checking the proportional hazards model assumptions and the stationarity assumption. We illustrate usage of the package with a simulated data example and a real dataset, the Channing House data, which are publicly available.