Statistics, Department of

 

The R Journal

Date of this Version

6-2017

Document Type

Article

Citation

The R Journal (June 2017) 9(1); Editor: Roger Bivand

Comments

Copyright 2017, The R Foundation. Open access material. License: CC BY 4.0 International

Abstract

This paper describes flan, a package providing tools for fluctuation analysis of mutant cell counts. It includes functions dedicated to the distribution of final numbers of mutant cells. Parametric estimation and hypothesis testing are also implemented, enabling inference on different sorts of data with several possible methods. An overview of the subject is proposed. The general form of mutation models is described, including the classical models as particular cases. Estimating from a model, when the data have been generated by another, induces different possible biases, which are identified and discussed. The three estimation methods available in the package are described, and their mean squared errors are compared. Finally, implementation is discussed, and a few examples of usage on real data sets are given.

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