Statistics, Department of

 

The R Journal

Date of this Version

12-2016

Document Type

Article

Citation

The R Journal (December 2016) 8(2); Editor: Michael Lawrence

Comments

Copyright 2016, The R Foundation. Open access material. License: CC BY 3.0 Unported

Abstract

Mixture toxicity assessment is indeed necessary for humans and ecosystems that are continually exposed to a variety of chemical mixtures. This paper describes an R package, called mixtox, which offers a general framework of curve fitting, mixture experimental design, and mixture toxicity prediction for practitioners in toxicology. The unique features of mixtox include: (1) constructing a uniform table for mixture experimental design; and (2) predicting toxicity of a mixture with multiple components based on reference models such as concentration addition, independent action, and generalized concentration addition. We describe the various functions of the package and provide examples to illustrate their use and show the collaboration of mixtox with other existing packages (e.g., drc) in predicting toxicity of chemical mixtures.

Share

COinS