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The purpose of this study was to examine whether the influence of key characteristics on adolescent alcohol misuse (is., maternal binge drinking, parenting, peers, school characteristics, and the adolescent's own behavior) change over time and whether predictors of adolescent alcohol misuse vary by gender and race/ethnicity. Using prospective, longitudinal data from a community sample, results revealed that mother's hinge drinking, peer drinking, and an early age of onset predicted higher levels of alcohol misuse when respondents were 14-16 years of age. Two years later, when adolescents were 16- 18 years of age, maternal binge drinking was no longer significant, however, maternal attachment, school attachment, peer drinking, and early age of onset were found to significantly predict adolescent alcohol misuse. Race differences were found for maternal binge drinking and gender differences were found for school suspension and maternal monitoring on adolescent drinking.