Synthetic Lethality in Pediatric Brain Cancer Cells by Optimized PLGA Nanoparticles and Drug Combinations

Authors

Megan Ruckman, University of Nebraska-LincolnFollow
Megan Otte, University of Nebraska-LincolnFollow
Forrest Kievit, University of Nebraska-LincolnFollow

Date of this Version

4-28-2020

Document Type

Poster

Abstract

Here we test drugs effectiveness to inhibit various DNA repair pathways with the purpose of sensitizing cancer cells to radiotherapy. We work on optimizing delivery of DNA repair pathway inhibiting drugs by the use of PLGA nanoparticles.