U.S. Department of Defense
Document Type
Article
Date of this Version
2007
Abstract
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
Comments
Published in Bioorganic & Medicinal Chemistry Letters 17 (2007) 1260–1265.