Novel 16S rRNA Methyltransferase RmtH Produced by Klebsiella pneumoniae Associated with War-Related Trauma

Authors

Jessica A. O'Hara, University of Pittsburgh - Main Campus
Patrick McGann, Walter Reed Army Institute of Research
Erik C. Snesrud, Walter Reed Army Institute of Research
Robert J. Clifford, Walter Reed Army Institute of Research
Paige E. Waterman, Walter Reed Army Institute of Research
Emil P. Lesho, Walter Reed Army Institute of Research
Yohei Doi, University of Pittsburgh - Main CampusFollow

Date of this Version

2013

Citation

Published in Antimicrobial Agents and Chemotherapy (2013) 57(5): 2413-2416. DOI:10.1128/AAC.00266-13

Abstract

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.