U.S. Department of Defense

 

Date of this Version

1987

Citation

Microbiological Reviews (1987), 51(2), p. 206-220.

Abstract

Introduction ........................ 206

Shiga Toxin in Shigella Spp. ........................ 207

History ........................ 207

Purification and Structure ........................ 207

Mode of Action ........................ 208

Receptor binding and internalization ........................ 208

Inhibition of protein synthesis ........................ 209

Immunology and Immunochemistry ........................ 209

Genetics ........................ 210

Role of Toxin in Disease ........................ 210

Dysentery ........................ 210

Diarrhea ........................210

HUS ........................ 211

Shiga-like toxins in E. Coli ........................ 211

History and Nomenclature ........................ 211

Discovery that EPEC and EHEC make Shiga-like toxins ........................ 211

Relationship of Shiga-like toxins to Vero toxins ........................ 212

Purification and Structure ........................ 212

Mode of Action ........................ 212

Immunology and Immunochemistry........................ 213

Genetics and Regulation ....................... 213

Role in Disease ........................ 215

Epidemiological evidence ........................ 215

Animal models ........................ 215

Shiga-like toxins in other bacteria ........................ 216

Conclusion ........................ 216

Acknowledgements .................................... . 216

Literature Cited .................................... 217

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