U.S. Department of Veterans Affairs
Relaxin Activates Peroxisome Proliferator-activated Receptor ƴ (PPARƴ) through a Pathway Involving PPAR ƴ Coactivator 1α (PGC1α)
Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 2, pp. 950–959, January 9, 2015
Background: Relaxin activates peroxisome proliferator-activated receptorƴ
(PPARƴ) by an unknown PPARƴ ligandindependent mechanism.
Results: Expression of PPARƴ coactivator 1α (PGC1α) was increased by relaxin through distinct signaling pathways.
Conclusion: The mechanism for relaxin regulation of PPARƴ is through increased PGC1α levels.
Significance: Discovery of new targets of relaxin signaling may provide further understanding of its pleiotropic effects.
US government work