Relaxin Activates Peroxisome Proliferator-activated Receptor ƴ (PPAR_ƴ) through a Pathway Involving PPAR _ƴ Coactivator 1α (PGC1α)

Authors

Sudhir K. Singh, Nebraska-Western Iowa Health Care System
Ronda L. Simpson, Nebraska-Western Iowa Health Care System
Robert G. Bennett, Department of Medical Research, Veterans Affairs Medical Center, 4101 Woolworth Ave., Omaha, NEFollow

Date of this Version

2015

Document Type

Article

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 2, pp. 950–959, January 9, 2015

Comments

US government work

Abstract

Background: Relaxin activates peroxisome proliferator-activated receptor_ƴ

(PPAR_ƴ) by an unknown PPAR_ƴ ligandindependent mechanism.

Results: Expression of PPAR_ƴ coactivator 1_α (PGC1_α) was increased by relaxin through distinct signaling pathways.

Conclusion: The mechanism for relaxin regulation of PPAR_ƴ is through increased PGC1_α levels.

Significance: Discovery of new targets of relaxin signaling may provide further understanding of its pleiotropic effects.