Veterinary and Biomedical Sciences, Department of


Date of this Version

October 2003


Published in JOURNAL OF VIROLOGY, Oct. 2003, p. 10714–10718 Vol. 77, No. 19. Copyright © 2003, American Society for Microbiology. Used by permission.


The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.