Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 2, pp. 1220–1228, January 6, 2012
Background: MOV10 inhibits HIV-1 replication after being packaged.
Results: A Gag binding plus all but one of seven helicase domains are required for MOV10 packaging. Nearly all residues are required for anti-HIV-1 activity. Conclusion: Gag binding is not sufficient for MOV10 packaging, and multiple discontinuous domains regulate MOV10 activity.
Significance: These findings uncover a new packaging mechanism and provide new insights into MOV10 antiviral activity.
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