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The susceptibility of eight rodent species to a range of widely used and candidate rodenticides was determined in laboratory feeding tests. No choice and choice tests were used to assess toxicity and effect on palatability of the rodenticides to Meriones shawi (Shaw's gerbil), Arvicanthis niloticus (Nile rat), Acomys cahirinus (Egyptian Spiny mouse), Mastomys natalensis (Multimammate rat), Sigmodon hispidus (Cotton rat), Rattus exulans (Polynesian rat), and R. rattus (Ship rat) which responded differently to each chemical. The results of these tests suggest possible rodenticides suitable for control of each species. Field trials are now needed to assess the effectiveness of these compounds under practical conditions.