The long-term research interest of my laboratory is to understand the molecular mechanisms underlying small RNA metabolism and function. Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), are 20 to 24 nucleotide (nt) RNAs that function as sequence-specific regulators of gene expression at both transcriptional and post-transcriptional levels in eukaryotes.
These small RNAs are involved in numerous cellular processes including development, differentiation, proliferation, apoptosis, and stress responses. We currently employ a combination of genetic, biochemical, cell biological, and genomic approaches to identify and characterize components involved in small RNA metabolism in Arabidopsis thaliana.

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2012

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The Chloroplast Triggers Developmental Reprogramming When MUTS HOMOLOG1 Is Suppressed in Plants, Ying-Zhi Xu, Roberto de la Rosa Santamaria, Kamaldeep S. Virdi, Maria P. Arrieta-Montiel, Fareha Razvi, Shaoqing Li, Guodong Ren, Bin Yu, Danny Alexander, Lining Guo, Xuehui Feng, Ismail M. Dweikat, Tom E. Clemente, and Sally A. MacKenzie

2010

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siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis, Bin Yu, Liu Bi, Jixian Zhai, Manu Agarwal, Shengben Li, Qingfa Wu, Shou-Wei Ding, Blake C. Meyers, Hervé Vaucheret, and Xuemei Chen

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siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis (Supplementary Material), Bin Yu, Liu Bi, Jixian Zhai, Manu Agarwal, Shengben Li, Qingfa Wu, Shou-Wei Ding, Blake C. Meyers, Hervé Vaucheret, and Xuemei Chen

2008

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The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis, Bin Yu, Binglian Zheng, Lijuan Ji, David Chevalier, Manu Agarwal, Vanitharani Ramachandran, Wanxiang Li, Thierry Lagrange, John C. Walker, and Xuemei Chen

2006

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HEN1 recognizes 21–24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide, Zhiyong Yang, Yon W. Ebright, Bin Yu, and Xuemei Chen

2002

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The pgp1 Mutant Locus of Arabidopsis Encodes a Phosphatidylglycerolphosphate Synthase with Impaired Activity, Changcheng Xu, Heiko Härtel, Hajime Wada, Miki Hagio, Bin Yu, Chris Eakin, and Christoph Benning

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Arabidopsis disrupted in SQD2 encoding sulfolipid synthase is impaired in phosphate-limited growth, Bin Yu, Changcheng Xu, and Christoph Benning