Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes

Authors

Evan Kesinger, University of Nebraska - Lincoln
Jianing Liu, University of Nebraska - Lincoln
Aaron Jensen, University of Nebraska - Lincoln
Catherine P. Chia, University of Nebraska - LincolnFollow
Andrew Demers, University of Nebraska - Lincoln
Hideaki Moriyama, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2018

Citation

PLoS ONE 13(6): e0199227

Comments

© 2018 Kesinger et al

Open access

https://doi.org/10.1371/journal.pone.0199227

Abstract

A new type of influenza virus, known as type D, has recently been identified in cattle and pigs. Influenza D virus infection in cattle is typically asymptomatic; however, its infection in swine can result in clinical disease. Swine can also be infected with all other types of influenza viruses, namely A, B, and C. Consequently, swine can serve as a "mixing vessel" for highly pathogenic influenza viruses, including those with zoonotic potential. Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective. Thus, it is necessary to develop an M2 ion channel blocker capable of suppressing the induction of resistance to the genetic shift. To provide a basis for developing novel ion channel- blocking compounds, we investigated the properties of influenza D virus M2 protein (DM2) as a drug target.