Date of this Version
Poster Presented at University of Nebraska-Lincoln Research Fair, April 4-5, 2017
Holistic repair of damaged cartilage remains an unsolved biomedical problem. Current methods that employ microfracture (MF) or autologous chondrocyte implantation (ACT) or tissue engineered strategies yield inferior repaired cartilage (Fig. 1). Lack of chondroinductive factors at the site of injury, in vivo, has been identified as a factor that limits repair. Clinically amenable strategies that can improve repair are desired. A novel clinically translatable repair strategy based on low-intensity-ultrasound (US) is proposed (Fig.2). Differently from all approaches that use US, our approach employs US at the cell resonant frequency where bioeffects are maximized. We have shown that US impacts the cellular response by promoting proliferation, chondrogenesis and healing at interfaces. In conjunction with the demonstration that US propagates in joint space, this work is impactful in the development of in vivo treatment strategies.