NMR and Metabolomics—A Roadmap for the Future

Authors

David S. Wishart, University of Alberta Faculty of Medicine and Dentistry
Leo L. Cheng, Massachusetts General Hospital, Harvard Medical School
Valérie Copié, Montana State University-Bozeman
Arthur S. Edison, University of Georgia
Hamid R. Eghbalnia, UConn Health
Jeffrey C. Hoch, UConn Health
Goncalo J. Gouveia, University of Georgia
Wimal Pathmasiri, University of North Carolina at Chapel Hill
Robert Powers, University of Nebraska - LincolnFollow
Tracey B. Schock, National Institute of Standards and Technology
Lloyd W. Sumner, University of Missouri
Mario Uchimiya, University of Georgia

Date of this Version

7-23-2022

Citation

Wishart, D.S.; Cheng, L.L.; Copié, V.; Edison, A.S.; Eghbalnia, H.R.; Hoch, J.C.; Gouveia, G.J.; Pathmasiri,W.; Powers, R.; Schock, T.B.; et al. NMR and Metabolomics—A Roadmap for the Future. Metabolites 2022, 12, 678. https://doi.org/10.3390/ metabo12080678

Comments

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

Abstract

Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatographymass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). While LC-MS methods are becoming increasingly popular in the field of metabolomics (accounting for more than 70% of published metabolomics studies to date), there are considerable benefits and advantages to NMR-based methods for metabolomic studies. In fact, according to PubMed, more than 926 papers on NMR-based metabolomics were published in 2021—the most ever published in a given year. This suggests that NMR-based metabolomics continues to grow and has plenty to offer to the scientific community. This perspective outlines the growing applications of NMR in metabolomics, highlights several recent advances in NMR technologies for metabolomics, and provides a roadmap for future advancements.