Chemistry, Department of: Faculty Series
David Berkowitz Publications
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Document Type
Article
Date of this Version
1995
Citation
J Org Chem. 1995 September ; 60(17): 5368–5369
Abstract
Analogues of natural amino acids, in which the α-proton is replaced by an unsubstituted epoxide ring, are potential mechanism-based inhibitors for pyridoxal phosphate dependent enzymes.1 Yet, free α-oxiranyl amino acids have remained elusive until now. The synthesis of an α-(phenyl-substituted)oxiranyl amino ester has been reported. However, the accessibility and stability of the corresponding free, zwitterionic α-oxiranyl amino acid remained an open question.9
Comments
Copyright 1995 Am. Chem. Soc.
doi:10.1021/jo00122a002