Searching for Smart Durable Coatings to Promote Bone Marrow Stromal Cell Growth While Preventing Biofilm Formation

Authors

Fereydoon Namavar, University of Nebraska Medical Center, 981080 Nebraska Medical Center, Omaha, NE
John D. Jackson, University of Nebraska Medical Center, 981080 Nebraska Medical Center, Omaha, NE
J. Graham Sharp, University of Nebraska Medical Center, 981080 Nebraska Medical Center, Omaha, NE
Ethan E. Mann, University of Nebraska Medical Center
Kenneth W. Bayles, University of Nebraska Medical CenterFollow
Chin Li Cheung, University of Nebraska-LincolnFollow
Connie A. Feschuk, University of Nebraska Medical Center
Shailaja Varma, University of Nebraska Medical Center
Hani Haider, University of Nebraska Medical Center
Kevin L. Garvin, University of Nebraska Medical Center

ORCID IDs

Kenneth W. Bayles

Date of this Version

1-8-2007

Comments

Published in Mater. Res. Soc. Symp. Proc. Vol. 954. Copyright © 2007 Materials Research Society. Used by permission.

Abstract

There is a great need to develop methods to regulate cellular growth in order to enhance or prevent cell proliferation, as needed, to either improve health or prevent disease. In this work we evaluated the adhesion, survival and growth of bone marrow stromal cells on the surface of several new ion beam engineered nano-crystals of ceramic hard coatings such as zirconium, titanium, tantalum and cerium oxides. Cell adhesion and growth on the ceramic coatings were compared to adhesion and growth on a nano-crystalline silver coating which is known to possess antibacterial properties. The initial results of a study to determine the effect of nanocrystalline titanium and silver coating on staphylococcus aureus biofilm growth is also discussed.