Applications of NMR to structure-based drug design in structural genomics

Authors

Robert Powers, University of Nebraska - LincolnFollow

Date of this Version

April 2002

Comments

Published in Journal of Structural and Functional Genomics 2 (2002), pp. 113–123. Copyright © 2002 Kluwer Academic Publishers. Used by permission. http://www.springerlink.com/content/1570-0267/

Abstract

Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inherent resolution are described in the context of structure-based drug design in the era of structural genomics.