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Investigation of the Biological Activity of Porphin Derivatives
Abstract
It has been known for over forty years that the products of the alkaline hydrolysis or saponification of chlorophyll exert remarkable effects on various mammalian and amphibian physiological systems. While the pharmacological investigations of this material in the past have been both varied and extensive, no specific chemical compound or com- pounds have been state to be responsible for the effects. This situa- tion is understandable since the treatment of chlorophyll by alkali gives rise to a great variety of compounds, the chemical constitution of which had not yet been established at the time of these pharmaco- logical investigations. Since the establishment of the chemical struc- ture and characteristics of the derivatives of chlorophyll by Hans Fis- cher, based upon the investigations of Willstaetter, Marchlewski, Conant and others, it is possible to isolate the specific derivatives arising from the alkaline treatment of chlorophyll to which structural formulas can now be assigned, and to study the pharmacology of the se derivatives.
Subject Area
Pharmacology
Recommended Citation
BERUEFFY, ROBERT RYAN, "Investigation of the Biological Activity of Porphin Derivatives" (1956). ETD collection for University of Nebraska-Lincoln. AAI0017356.
https://digitalcommons.unl.edu/dissertations/AAI0017356