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2,4-Disubstituted quinoline derivatives
Abstract
Among the first organic compounds known that contained the quinoline muscles was a mixture of cinchona alkaloids discovered in the bark of certain trees by the aborigines of the Andean highlands of South America in their search for natural products of medicinal value. Quinine, the most important of this series of alkaloids, has many physiological effects but one of the most useful is its antipyretic action, especially in malaria fever. Although its use as an anti- pyretic was recognized by the more civilized world in 1638, the present accepted structure of the drug was not elucidated 2 until the work of Rabe in 1909.
Subject Area
Inorganic chemistry|Chemistry
Recommended Citation
Buchmann, Fred J, "2,4-Disubstituted quinoline derivatives" (1941). ETD collection for University of Nebraska-Lincoln. AAIDP13689.
https://digitalcommons.unl.edu/dissertations/AAIDP13689