Bioinformatic identification and characterization of human endothelial cell-restricted genes

Authors

Manoj Bhasin, Harvard Medical School
Lei Yuan, Harvard Medical School
Derin B. Keskin, Dana-Farber Cancer Institute
Hasan H. Otu, Harvard Medical SchoolFollow
Towia A. Libermann, Harvard Medical School
Peter Oettgen, Harvard Medical SchoolFollow

ORCID IDs

Hasan H. Otu

Document Type

Article

Date of this Version

2010

Citation

BMC Genomics 2010, 11:342

Comments

© 2010 Bhasin et al

Open access

doi:10.1186/1471-2164-11-342

Abstract

Background: In this study, we used a systematic bioinformatics analysis approach to elucidate genes that exhibit an endothelial cell (EC) restricted expression pattern, and began to define their regulation, tissue distribution, and potential biological role.

Results:Using a high throughput microarray platform, a primary set of 1,191 transcripts that are enriched in different primary ECs compared to non-ECs was identified (LCB >3, FDR

Conclusion: The study provides an initial catalogue of EC-restricted genes most of which are ubiquitously expressed in different endothelial cells.