Entomology, Department of

 

Authors

Joseph Mathu Ndung’u, Foundation for Innovative New Diagnostics, Switzerland
Alain Boulangé, Centre International de Recherche-Developpement sur l’Elevage en zone Subhumide, Bobo-Dioulasso
Albert Picado, Foundation for Innovative New Diagnostics, Switzerland
Albert Mugenyi, Coordinating Office for Control of Trypanosomiasis in Uganda (COCTU)
Allan Mortensen, Vestergaard SA
Andrew Hope, Liverpool School of Tropical Medicine
Brahim Guihini Mollo, Institut de Recherche en Elevage pour le Développement
Bruno Bucheton, Université de Montpellier
Charles Wamboga, Uganda Ministry of Health
Charles Waiswa, Coordinating Office for Control of Trypanosomiasis in Uganda (COCTU)
Dramane Kaba, Institut Pierre Richet Bouake
Enock Matovu, Makerere University
Fabrice Courtin, Université de Montpellier
Gala Garrod, Liverpool School of Tropical Medicine
Geoffrey Gimonneau, Centre International de Recherche-Developpement sur l’Elevage en zone Subhumide, Bobo-Dioulasso
Georgina Bingham, University of Nebraska-LincolnFollow
Hassane Mahamat Hassane, Institut de Recherche en Elevage pour le Développement
Inaki Tirados, Liverpool School of Tropical Medicine
Isabel Saldanha, Liverpool School of Tropical Medicine
Jacques Kabore, Centre International de Recherche-Developpement sur l’Elevage en zone Subhumide, Bobo-Dioulasso
Jean Baptiste Rayaisse, Centre International de Recherche-Developpement sur l’Elevage en zone Subhumide, Bobo-Dioulasso
Jean Mathieu Bart, Université de Montpellier
Jessica Lingley, Liverpool School of Tropical Medicine
Johan Esterhuizen, Liverpool School of Tropical Medicine
Joshua Longbottom, Liverpool School of Tropical Medicine
Justin Pulford, Liverpool School of Tropical Medicine
Lingue Kouakou, Programme National d’Elimination de la THA (PNETHA)
Lassina Sanogo, Centre International de Recherche-Developpement sur l’Elevage en zone Subhumide, Bobo-Dioulasso
Lucas Cunningham, Liverpool School of Tropical Medicine
Mamadou Camara, Université de Montpellier
Mathurin Koffi, Université Jean Lorougnon Guédé
Michelle Stanton, Liverpool School of Tropical Medicine
Mike Lehane, Liverpool School of Tropical Medicine
Moise Saa Kagbadouno, Programme National de Lutte contre la Trypanosomiase Humaine Africaine
Oumou Camara, Programme National de Lutte contre la Trypanosomiase Humaine Africaine
Paul Bessell, Epi Interventions
Peka Mallaye, Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA)
Philippe Solano, Université de Montpellier
Richard Selby, Liverpool School of Tropical Medicine
Sophie Dunkley, Liverpool School of Tropical Medicine

Document Type

Article

Date of this Version

11-1-2020

Citation

Ndung’u JM, Boulange´ A, Picado A, Mugenyi A, Mortensen A, Hope A, et al. (2020) Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies. PLoS Negl Trop Dis 14(11): e0008738. https://doi. org/10.1371/journal.pntd.0008738

Comments

Copyright: © 2020 Ndung’u et al. This is an open access article distributed under the terms of the Creative Commons Attribution License

Abstract

Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while Trypanosoma brucei rhodesiense causes an acute form in eastern Africa. g-HAT is targeted for elimination as a public health problem by 2020 and 0 transmission by 2030 [1,2]. Control of g-HAT is largely based on identification and treatment of infected individuals, supplemented by control of the tsetse fly vectors [3]. There has been growing evidence that when both tsetse control and case identification activities are carried out simultaneously in the same geographies, elimination of the disease is accelerated [4–6]. Here, we describe how the Trypa-NO! Partnership is using novel and classical tools to drive g-HAT elimination in an integrated approach, progress made, lessons learnt, and future directions.

The Trypa-NO! Partnership was established in September 2016 to support National Sleeping Sickness Control Programmes (NSSCP) in Chad, Coˆte d’Ivoire, Republic of Guinea, and Uganda in driving elimination of g-HAT by integrating tsetse control with screening, diagnosis, and treatment of cases. The Partnership goals are to drive to 0 the annual number of g- HAT cases reported in Coˆte d’Ivoire and Uganda by 2020 and reduce cases by 90% in the Republic of Guinea and Chad by 2022.

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